Most initiatives to enhance vulnerability analysis focus on implementing new technological approaches into products and processes. However, recent advancements in the field highlight the importance of integrating Human-System Integration (HSI) in designing, building, and using vulnerability analysis systems to achieve progress. Integrating HSI into these technologies requires accounting for human factors such as attention, decision-making processes, and cognitive workload. This paper examines the significance of HSI in vulnerability analysis and the potential benefits of integrating human variables into the process. Furthermore, this paper underlines successful applications of HSI in vulnerability analysis across various domains, including aviation security, cybersecurity, and disaster management. Overall, this paper emphasizes the significance of HSI in enhancing vulnerability analysis in strengthening security and decreasing risk.