Leakages in industrial building roofs is the common phenomenon on old and new buildings due to lack of quality of works done during execution phase, which not only affects normal use of house, and erodes the main structure of buildings, but brings about great challenge to infrastructure maintenance and seriously shortens service life of buildings. Starting with the common causes for roof leakage on large industrial buildings while combining with engineering practice, this paper discussed how to prevent and control of roof leakage on industrial buildings so as to reduce the significant harm brought with.